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Zhu Huanhu Lab

NUTRIENT, METABOLISM AND ANIMAL DEVELOPMENT
Research Area: Environment Factors on Developmental Regulation
Research Interests:
The interplay between animal and the environment helped to shape the physiological and developmental program in animals. To better understand this process, we apply a nematode C. elegans model to study the role of several key environmental factors such as nutrient molecule, pheromone and gut bacteria. We are surprised to find those environments play vital roles and fundamentally arbitrate the animal developmental fate and the native immunity.
 


 Huanhu ZHU, Principal Investigator

Affiliation: School of Life Science and Technology, ShanghaiTech University
Education Background:
1998-2002, Fudan University CHINA, B.S.
2002-2010, Fudan University CHINA, Ph.D.
Working Experience:
2009-2015, University of Colorado Boulder, HHMI, Research associate
2015/11-Present, ShanghaiTech University, Assistant Professor (TENURE-TRACK)


Dr. Huanhu Zhu obtained his bachelor and doctor degrees from Fudan University. He studied the functions of lipids and proteins that suppress tumor growth and metastasis in Drosophila melanogaster under his Ph.D. advisors Dr. Tian Xu and Dr. Xiaohui Wu (Fudan Univ.). He then joined Dr. Min Han’s lab (HHMI/Univ. of Colorado, Boulder) in 2010 to further understand how branched-chain lipids regulate development and physiological functions in Caenorhabditis elegans. In October 2015, Dr. Huanhu Zhu joined School of Life Science and Technology of ShanghaiTech University as an assistant professor.
Honors and Awards:
1. 2016 National 1000-talents Plan (Youth)
2. 2016 Shanghai Pujiang Program
3. ShanghaiTech Excellent Teacher Award 2017
4. ShanghaiTech Best Tutor Award 2018
5. ShanghaiTech Excellent Teacher Award 2019
Funding:
1. 2021-2025 National Natural Science Foundation of China 32170837
2. 2019-2024 Ministry of Science and Technology of China 2019YFA0802800 (attendance)
3. 2016-2018 Shanghai Science and Technology, 16PJ1407400

4. 2021-2026 Ministry of Science and Technology of China 2021YFA0804700 (attendance)
5. 2022 Double First-Class Initiative Fund of ShanghaiTech University SYLDX0162022

 PUBLICATIONS

Li, N., Hua, B., Chen, Q., Ruan, M., Teng, F., Zhu, M., Zhang, L., Huo, Y., Liu, X., Zhuang, M., Shen, H., Zhu, H. #
A sphingolipid-mTORC1 nutrient-sensing pathway regulates animal development by an intestinal peroxisome relocation-based gut-brain crosstalk
Cell Reports 40(4), 111140, 2022. DOI:https://doi.org/10.1016/j.celrep.2022.111140

 

Liu, Y., Zhou, Z., Yin, L., Zhu, M., Wang, F., Zhang, L., Wang, H., Zhou, Z., Zhu, H#., Huang, C.#, Fan, S#.
Tangeretin promotes lifespan associated with insulin/insulin-like growth factor-1 signaling pathway and heat resistance in Caenorhabditis elegans.
BioFactors 48, 442-453.2022.

 

Zhu, M.*, Teng, F.*, Li, N., Zhang, L., Zhang, S., Xu, F., Shao, J., Sun, H., and Zhu, H#.
Monomethyl branched-chain fatty acid mediates amino acid sensing upstream of mTORC1.
Developmental Cell 56, 2692-2702.e2695.

F Wang, Y Dai, X Zhu, Q Chen, H Zhu, B Zhou, H Tang & S Pang.
Saturated very long chain fatty acid configures glycosphingolipid for lysosome homeostasis in long-lived C. elegans.
Nat Commun 12, 5073 (2021). https://doi.org/10.1038/s41467-021-25398-6

Y Zhang, X Sun, Y Qian Y, H Yi, K Song, H Zhu, F Zonta, W Chen, Q Ji, S Miersch, SS Sidhu, D Wu.
A potent anti-SpuE antibody allosterically inhibits type III secretion system and attenuates virulence of Pseudomonas aeruginosa
J Mol Biol. 2019 Nov 2. pii: S0022-2836(19)30622-9. doi: 10.1016/j.jmb.2019.10.026.

S Mao, Y Qi, H Zhu, X Huang, Y Zou, T Chi
A Tet/Q Hybrid System for Robust and Versatile Control of Transgene Expression in C. elegans
iScience, 2019 January;11(25): 224-237 doi: https://doi.org/10.1016/j.isci.2018.12.023

H Zhu#
Our gut bacteria may act as a foe of our brain.
AME medical Journal, editorial 2017 2.87 doi: 10.21037/amj.2017.05.19

L Ying and H Zhu# (corresponding author).
Current advances in the functional studies of fatty acids and fatty acid-derived lipids in C. elegans Worm, invited mini-review 2016 May 04: 5(3) e1184814 doi: 10.1080/21624054.2016.1184814.

H Zhu*# (corresponding author and co-first author), AK Sewell*, and M Han.
Intestinal apical polarity mediates regulation of TORC1 by glucosylceramide in C. elegans. Genes & Development, 2015 Jun 15;29(12):1218-23 doi:10.1101/gad.263483.115

M Kniazeva, H Zhu and M Han
A lipid-TORC1 pathway promotes neuronal development and functions involved in food responses in C. elegans. Developmental Cell, 2015 May 4;33(3):260-71. doi: 10.1016/j.devcel.2015.02.015.

H Zhu# (corresponding author) and M Han
Exploring developmental and physiological functions of fatty acid and lipid variants through worm and fly genetics. Annual Review of Genetics, 2014;48:119-48. doi: 10.1146/annurev-genet-041814-095928. Epub 2014 Aug 25.

J Ren, H Zhu, C Chi, M Mehrmohamadi, K Deng, X Wu, T Xu.
Beadex affects gastric emptying in Drosophila. Cell Res. 2014 May;24(5):636-9. doi: 10.1038/cr.2014.24.

H Zhu, H Shen, AK Sewell, M Kniazeva, M Han.
A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans. eLife. 2013 May 21;2:e00429. doi: 10.7554/eLife.00429

C Chi*, H Zhu* (Co-first author), M Han, Y Zhuang, X Wu, T Xu.
Disruption of lysosome function promotes tumor growth and metastasis in Drosophila. J Biol Chem. 2010 Jul 9;285(28):21817-23.

L Kang, X Ma, L Cai, S Liao, L Sun, H Zhu, X Chen, D Shen, S Zhao, C Li: Superinfection of Laodelphax striatellus with Wolbachia from Drosophila simulans, Heredity Vol. 90, 71-76, 2003

L Kang, H Zhu, Q Cheng, W Zhou, L Sun, L Cai, X Ma, C Chen, S Zhao, C Li.
Cloning and characterization of a gene encoding glutathione-regulated potassium-efflux system protein KefKL from the endosymbiont Wolbachia
DNA Sequence (Now called Mitochondrial DNA), Vol. 13, 375-381, 2002

 

CONTACT INFORMATION
Office Landline: +86-21-20684523
Email: Zhuhh1@@shanghaitech.edu.cn


Mailing Address:
Room B206, L Building, School of Life Science and Technology,
ShanghaiTech University,
No.1 Zhongke Road, Pudong District,

Shanghai CHINA, 201210
 

ABOUT SHANGHAITECH UNIVERSITY
ShanghaiTech is a young university with a modern residential campus in the heart of Shanghai Pudong’s Zhangjiang Hi-Tech Park. With an academic focus on STEM research, ShanghaiTech is committed to serving China’s national challenges in economic and social development with the focus on science and technology, and nurturing the next generation of innovative scientists, inventors and entrepreneurs. School of Life Science and Technology aims to develop into a world-class, research-oriented school in life science and technology, drawing strength not only from its outstanding full-time faculty but also from two affiliated world-class biomedical research institutes at ShanghaiTech (including three laboratories led by Nobel laureates) as well as from select faculty members jointly appointed with institutes of Chinese Academy of Sciences in Shanghai who conduct world-class research. In addition, SLST have priority access to the state-of-art National Research Facilities, and are developing close collaborations with its neighboring R&D centers of multinational pharmaceutical and biotech companies in Zhangjiang High-tech Park: the "Biopharma Valley" of China.